1, 6-Dihydro-3 (2H)-pyridinones. IX. A Regioselective Synthesis of Ethyl 3-Methoxycarbonylmethyl-4-oxopiperidine-1-carboxylate from Ethyl 3-Hydroxy-1, 2, 3, 6-tetrahydropyridine-1-carboxylate

Abstract

The title compound (6) was prepared from ethyl 3-hydroxy-1, 2, 3, 6-tetrahydropyridine-1-carboxylate (2) via a regioselective hydroxylation at the C-4 position of the olefin (7) by utilizing an iodolactonization reaction.