Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Studies on Peptides. CXIV. Synthesis of Hylambates-Kassinin, a Frog Skin Tachykinin Peptide
NOBUTAKA FUJII, SHINICHI KATAKURA, HARUAKI YAJIMA, YOSHIHIRO NAKATA, ATSUKO INOUE, TOMIRO SEGAWA
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Keywords: contractile activity
JOURNAL FREE ACCESS

1983 Volume 31 Issue 12 Pages 4259-4262

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Abstract
Hylambates-kassinin, a new amphibian skin dodecapeptide of the tachykinin family, was synthesized in a conventional manner using thioanisole-mediated deprotection with trifluoromethanesulfonic acid. The contractile potency of synthetic hylambates-kassinin in isolated guinea-pig duodenum was 1.4 times higher than that of synthetic kassinin.
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© The Pharmaceutical Society of Japan
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