Synthesis of dl-9 (O)-Methano-△⁶-prostaglandin I₁

Abstract

Biologically interesting 9 (O)-methano-△⁶-prostaglandin I₁ (9 (O)-methano-△⁶-PGI₁), a chemically stable analog of prostacyclin (PGI₂), was efficiently synthesized from 1, 3-cyclooctadiene with high stereo- and regiochemical control. In all three biological test systems examined, 9 (O)-methano-△⁶-PGI₁ was found to be considerably less active than prostaglandin E₁ (PGE₁).