Abstract
A computer optimization technique was applied to obtain flufenamic acid (FFA)/polyvinylpolypyrrolidone (PVPP)/methyl cellulose (MC) solid dispersions which provide a high dissolution rate and high stability of FFA. The amounts of PVPP, MC and ethanol were selected as independent variables. Both PVPP and MC are formulation variables, and ethanol, which was used for the preparation of solid dispersions, is a process variable. Twelve dissolution parameters were selected as dependent variables for deciding the optimum formulation. These dissolution parameters were predicted quantitatively by the best combination of independent variables. The physical significance of the regression equation for each dissolution parameter was defined with the application of contour graphs. The optimum formulation of FFA/PVPP/MC solid dispersions was obtained by placing a set of restrictions on the regression equations. Experimental results for the optimum formulation agreed well with the predictions.
