Configuration at the C-23 Position of 23-Hydroxy- and 23, 25-Dihydroxycholesterols

Abstract

(23R)- and (23S)-23-Hydroxy- and 23, 25-dihydroxycholesterols were synthesized via 3β-tetrahydropyranyloxycholesta-5, 25-dien-23-ol (5) from cholenic acid acetate (1). The stereochemistry at the C-23 position of related steroids is also discussed.