Chaetoglobosins, Cytotoxic 10-(Indol-3-yl)-[13] cytochalasans from Chaetomium spp. IV. ¹³C-Nuclear Magnetic Resonance Spectra and Their Application to a Biosynthetic Study

Abstract

Assignments of the ¹³C-nuclear magnetic resonance signals of eight naturally occurring chaetoglobosins were established. Incorporations of [1-¹³C]-, [2-¹³C]-, and [1, 2-¹³C₂]-acetate, [¹³C-methyl]-L-methionine, and [1-¹³C]-and [2-¹³C]-DL-tryptophan into chaetoglobosins A and C by Chaetomium globosum demonstrated that the molecules were formed from nine units of acetate/malonate, three C₁ units, and one unit of tryptophan.