Abstract
The size reduction of chloramphenicol palmitate to a submicron level was accomplished by the freeze-drying of a solution composed of chloramphenicol palmitate and benzene. The crystal form of the resulting powder was characterized by using X-ray diffractometry, infrared spectroscopy, and differential scanning calorimetry (DSC). The first two methods showed the powder to be polymorph B, but DSC measurements indicated that it contains a trace (or seeds) of polymorph A. This was confirmed by hot-stage microscopy. The dissolution rates and solubilities of freeze-dried powders and polymorph A were determined.
