Preparation of an Ion-selective Electrode Sensitve to Flufenamic Acid Anion and Its Application to the Study of Protein Binding of Flufenamate in Aqueous Solution

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A polyvinyl chloride (PVC) matrix membrane electrode sensitive to flufenamic acid anion was prepared. The membrane contained trioctylmethylammonium flufenamate as an ion exchanger. The electrode showed the Nernstian response for the flufenamate anion in the concentration range of 3×10^-5 to 7×10^-4м (25°C). The response was independent of pH in the range of pH 6.2 to 9. The selectivity coefficients for chloride and nitrate ions were less than 10^-3, but the electrode showed almost the same sensitivity to mefenamate anion as to flufenamate. Addition of bovine serum albumin caused a marked change in the response curve, indicating that an interaction occurred between flufenamate and the protein.