Abstract
The effects of two long-chain alcohols (stearyl alcohol, and cetyl alcohol) on predni-solone (PD) release in vitro from o/w type ointment bases were studied. When cetyl alcohol alone or mixtures of the two alcohols in various ratios were added to the o/w type ointment bases, the PD release rates were almost the same. On the other hand, when stearyl alcohol alone was added to the o/w type ointment base, the PD release rate was faster than those from the other ointment bases. In order to confirm the above results, measurements of viscosity, and water penetration rate into the o/w type ointment base were carried out. It was found that the release rate of PD from o/w type ointment base was inversely proportional to its viscosity, and was proportional to the water penetration rate into the base.
