Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
STRUCTURE OF β-CYCLODEXTRIN INCLUSION COMPLEX WITH NICOTINAMIDE
原田 一明河野 健治福永 和弘大谷 淑郎
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キーワード: crystal structure
ジャーナル フリー

1983 年 31 巻 4 号 p. 1428-1430

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抄録
The crystal structure of the β-cyclodextrin-nicotinamide (1 : 1) complex hexahydrate was determined by the X-ray method. The β-cyclodextrin ring is round in shape with seven intramolecular hydrogen bonds between secondary hydroxyl groups. The nicotinamide molecule is included in the host β-cyclodextrin cavity with the pyridine moiety being located at the center of the cavity. The amido group protrudes outside from the primary hydroxyl side of β-cyclodextrin and forms hydrogen bonds with adjacent β-cyclodextrin and water molecules.
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© The Pharmaceutical Society of Japan
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