SYNTHESIS OF A NEW POTENT ANTI-ULCER AND GASTRIC SECRETORY INHIBITING AGENT, (-)-cis-2, 3-DIHIDRO-3-(4-METHYLPIPERAZINYLMETHYL)-2-PHENYL-1, 5-BENZOTHIAZEPIN-4 (5H)-ONE HYDROCHLORIDE (BTM-1086), AND RELATED COMPOUNDS

Abstract

(-)-cis-2, 3-Dihydro-3-(4-methylpiperazinylmethyl)-2-phenyl-1, 5-benzothiazepin-4 (5H)-one hydrochloride (BTM-1086) and its analogues, which possessed potent anti-ulcer and gastric secretory inhibiting activities, were synthesized and the structures of these compounds were established on the basis of spectral and chemical evidences.