Abstract
Reaction of ethyl 4-bromoacetoacetate (1) with 2-cyanoethene-1, 1-dithiol derivatives (prepared from carbon disulfide and active methylene compounds such as ethyl cyanoacetate and malononitrile in the presence of sodium hydride) gave 2-substituted 4-hydroxy-1, 3-dithiolane-4-acetates, 2a and 2b. On the other hand, reaction of 1 with 2-cyano-1-methylthioethene-1-thiol derivatives (prepared from 2-cyanoethene-1, 1-dithiol derivatives and methyl iodide) gave 4-substituted 3-amino-5-methylthiothiophene-2-(3-oxo) propionates, 5a and 5b.
