Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Enhancement of Dissolution Properties of Prednisolone from Ground Mixtures with Chitin or Chitosan
YOICHI SAWAYANAGINAOKI NAMBUTSUNEJI NAGAI
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Keywords: dissolution rate
JOURNAL FREE ACCESS

1983 Volume 31 Issue 7 Pages 2507-2509

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Abstract
With a view to an application of chitin and chitosan to pharmaceutical preparations, the dissolution behavior of ground mixtures of prednisolone with chitin and chitosan was investigated. Ground mixtures of prednisolone with chitin and chitosan were prepared by cogrinding in a ball mill. The X-ray diffraction patterns and results of differential scanning calorimetry suggested that the size of crystals of prednisolone was decreased in the ground mixtures. The dissolution rate of prednisolone from the ground mixtures was significantly greater than that from the physical mixture or from intact prednisolone powder. These results indicate that chitin and chitosan can improve the dissolution properties of prednisolone.
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© The Pharmaceutical Society of Japan
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