Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
SPECIFIC REMOVAL OF 5-CHLORO-8-QUINOLYL PROTECTING GROUP OF INTERNUCLEOTIDIC BONDS
釜池 和夫上田 惣一土屋 弘道高久 洋
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1983 年 31 巻 8 号 p. 2928-2931

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抄録
5-Chloro-8-quinolyl protecting group of internucleotidic bonds was efficiently removed by treatment with zinc acetate or 2-pyridine-carboxaldehyde oxime at room temperature. On the other hand, alkaline hydrolysis of phosphotriester intermediates with free 3'-hydroxyl function (2a) leads to the formation of 3'-3'in addition to 3'-5'-inter-nucleotidic bonds.
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© The Pharmaceutical Society of Japan
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