Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ELUCIDATION OF THE STRUCTURE OF OLIVORETIN A AND D (TELEOCIDIN B)
Shinichiro SakaiNorio AimiKeiichi YamaguchiYukio HitotsuyanagiChitoshi WatanabeKazuteru YokoseYasumasa KoyamaKoichi ShudoAkiko Itai
Author information
Keywords: X-ray analysis
JOURNALS FREE ACCESS

1984 Volume 32 Issue 1 Pages 354-357

Details
Abstract

The known metabolites, indole-3-aldehyde, indole-3-carboxylic acid, cyclo-Leu-Val, cyclo-Pro-Leu and phenyl acetamide were isolated from Streptoverticillium olivoreticuli together with pimprinin derivatives. Four more complex natural products having strong vesicatory toxicity, olivoretin A, B, C and D, were also isolated and based on the chemical correlation with D, A was proved to be O-methyl olivoretin D. By X-ray analysis the structure of olivoretin D, having strong epigenetic activities, was found to have exactly the same structure as teleocidin B.

Information related to the author
© The Pharmaceutical Society of Japan
Previous article Next article
feedback
Top