抄録
The metabolism of an antibacterial nitrofuran, furazolidone (N-(5-nitro-2-furfurylidene)-3-amino-2-oxazolidone), was investigated in eels. When eels were bathed in a solution of the nitrofuran, ethyl acetate-extractable metabolites and polar, water-soluble metabolite (s) were formed from the nitrofuran. One of the former metabolites was isolated from the bathing solution and unequivocally identified as 3-(4-cyano-2-oxobutylideneamino)-2-oxazolidone by comparison with an authentic sample. This metabolite was also formed from the nitrofuran by an eel liver homogenate-catalyzed reaction.
