Author's Organization：Faculty of Pharmaceutical Sciences, University of Tokyo Faculty of Pharmaceutical Sciences, University of Tokyo Faculty of Pharmaceutical Sciences, University of Tokyo Faculty of Pharmaceutical Sciences, University of Tokyo
Induction of terminal differentiation of human myelogenous leukemia cells, HL-60, was caused by terephthalic acid mono-5, 5, 8, 8-tetramethyl-5, 6, 7, 8-tetrahydro-2-naphthylamide. The differentiated cells are morphologically and functionally granulocyte-like. The minimum concentration for detectable activity is less than 10-10M (0.04 ng/ml), and differentiation reaches a maximum at about 10-8-10-9M.
