Furo [3, 2-b] indole Derivatives. I. Synthesis and Analgesic and Anti-inflammatory Activities of 4, 6-Disubstituted-furo [3, 2-b] indole-2-carboxamide Derivatives

Abstract

N-(3-Piperidinopropyl)-4, 6-disubstituted-furo [3, 2-b] indole-2-carboxamide derivatives were prepared and examined for analgesic and anti-inflammatory activities using the acetic acid writhing method in mice and the carrageenin edema method in rats. Some of the compounds were found to have potent and anti-inflammatory activities in the animal model.