Effect of Simultaneous Administration of Drugs on Absorption and Excretion. XVIII. Differential Effects of Oral and Rectal Administration of Chloral Hydrate on the Gastrointestinal Absorption of Sulfisoxazole in Rabbits

Abstract

The effects of oral and rectal administration of chloral hydrate (CH) on the gastrointestinal absorption of sulfisoxazole (SIX) were investigated in rabbits. The blood concentration data for SIX led us to conclude that the oral administration of CH causes an enhancement in SIX absorption, whereas the rectal administration of CH causes a reduction in SIX absorption. It is noteworthy that the route of administration plays an important role in the SIX-CH interaction involved in the gastrointestinal absorption. In addition, the factors determining the differential effects of oral and rectal administration of CH on the gastrointestinal absorption of SIX are discussed.