Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Synthesis and Gastric Antisecretory Activity of N-Cyano-N'-(phenyl-pyridinylmethyl) guanidine Derivatives
KATSUTOSHI SHIMADAHIDEAKI FUJISAKIKIYOSHI OKETANIMANABU MURAKAMITADAO SHOJITSUNEO WAKABAYASHIKOICHIRO UEDAKIICHI EMAKAZUNORI HASHIMOTOSATORU TANAKA
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1984 Volume 32 Issue 12 Pages 4893-4906

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Abstract

N-Alkyl-N'-cyano-N"-(substituted phenyl-pyridinylmethyl) guanidine derivatives were synthesized and tested for inhibitory activity against gastric secretion in rats. Several of the compounds synthesized showed an inhibiting activity as potent as that of cimetidine against basal gastric secretion but showed less potent activity than cimetidine against histamine-stimulated gastric secretion. Some structure-activity relationships are discussed.

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© The Pharmaceutical Society of Japan
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