Synthesis and Gastric Antisecretory Activity of N-Cyano-N'-(phenyl-pyridinylmethyl) guanidine Derivatives

KATSUTOSHI SHIMADA; HIDEAKI FUJISAKI; KIYOSHI OKETANI; MANABU MURAKAMI; TADAO SHOJI; TSUNEO WAKABAYASHI; KOICHIRO UEDA; KIICHI EMA; KAZUNORI HASHIMOTO; SATORU TANAKA

doi:10.1248/cpb.32.4893

KATSUTOSHI SHIMADA, HIDEAKI FUJISAKI, KIYOSHI OKETANI, MANABU MURAKAMI, TADAO SHOJI, TSUNEO WAKABAYASHI, KOICHIRO UEDA, KIICHI EMA, KAZUNORI HASHIMOTO, SATORU TANAKA

Author information

KATSUTOSHI SHIMADA
HIDEAKI FUJISAKI
KIYOSHI OKETANI
MANABU MURAKAMI
TADAO SHOJI
TSUNEO WAKABAYASHI
KOICHIRO UEDA
KIICHI EMA
KAZUNORI HASHIMOTO
SATORU TANAKA
Author's Organization：
Eisai Tokyo Research Laboratories
Eisai Tsukuba Research Laboratories
Eisai Tsukuba Research Laboratories
Eisai Tsukuba Research Laboratories
Eisai Tsukuba Research Laboratories
Eisai Tsukuba Research Laboratories
Eisai Tokyo Research Laboratories
Eisai Tokyo Research Laboratories
Eisai Tokyo Research Laboratories
Eisai Tokyo Research Laboratories

Keywords: histamine H₂ antagonist

JOURNAL FREE ACCESS

1984 Volume 32 Issue 12 Pages 4893-4906

DOI https://doi.org/10.1248/cpb.32.4893

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Abstract

N-Alkyl-N'-cyano-N"-(substituted phenyl-pyridinylmethyl) guanidine derivatives were synthesized and tested for inhibitory activity against gastric secretion in rats. Several of the compounds synthesized showed an inhibiting activity as potent as that of cimetidine against basal gastric secretion but showed less potent activity than cimetidine against histamine-stimulated gastric secretion. Some structure-activity relationships are discussed.

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