Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Synthesis of Antimicrobial Agents. VI. Studies on the Synthesis of Furo [3, 2-b] [1, 8] naphthyridine Derivatives
ISAO HAYAKAWANORIO SUZUKIKAZUNORI SUZUKIYOSHIAKI TANAKA
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1984 Volume 32 Issue 12 Pages 4914-4922

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Abstract

As a part of our search for new antibacterial agents, 5-ethyl-8-oxo-5, 8-dihydrofuro [3, 2-b]-[1, 8] naphthyridine-7-carboxylic acid and its 2, 3-dihydrofuro derivative, the 4-aza analogue of droxacin, were synthesized and their antibacterial activities were tested. Both compounds exhibited high antibacterial activities and a broad antibacterial spectrum. In an attempt to find a suitable method for industrial-scale synthesis of these compounds, several methods for the furan ring cyclization of 6, 7-disubstituted 1, 8-naphthyridine-3-carboxylate derivatives were compared.

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© The Pharmaceutical Society of Japan
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