Abstract
The behavior of 1 : 1 inclusion complexes between cyclodextrins (CyD) and bencyclane (Ben) in a two-liquid-phase system of octanol and water was quantitatively investigated by measurement of partition coefficients (PC method). It was found that octanol partially prevents the formation of CyD·Ben complex and the apparent formation constant (K') was calculated from the apparent partition coefficient (P*). This phenomenon was also observed in general with CyD 1 : 1 inclusion complexes of various drugs. The corrected formation constants (K) of these complexes in the aqueous phase were determined from the K' values by applying the equilibrium equations.
