Synthesis of dl-9 (O)-Methanoprostaglandin-I₁

Abstract

The synthesis of both 9 (O)-methano-6α-prostaglandin-I₁ (9 (O)-methano-6α-PGI₁) and 9 (O)-methano-6β-prostaglandin-I₁ (9 (O)-methano-6β-PGI₁) has been accomplished via the same synthetic intermediate obtainable from 1, 3-cyclooctadiene. These analogs showed weak inhibitory activity in rabbit platelet aggregation induced by adenosine diphosphate. Furthermore, 9 (O)-methano-6β-PGI₁ did not show any cytoprotective action on rabbit, stomach epithelial cells at the concentration of 10^<-6 M.