Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Studies on Peptides. CXVII. Solution Synthesis of the Tetratetracontapeptide Amide Corresponding to the Entire Amino Acid Sequence of Growth Hormone Releasing Factor, Somatocrinin
NOBUTAKA FUJIIMASANORI SHIMOKURAMOTOYOSHI NOMIZUHARUAKI YAJIMAFUMIAKI SHONOMASAFUMI TSUDAAKIRA YOSHITAKE
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Keywords: rat growth hormone
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1984 Volume 32 Issue 2 Pages 520-529

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Abstract
The tetratetracontapeptide corresponding to the entire amino acid sequence of growth hormone releasing peptide derived from human pancreas islet tumor was synthesized by assembling eight peptide fragments in a conventional manner, followed by thioanisole-mediated deprotection with 1 M trifluoromethanesulfonic acid in TFA. Our synthetic peptide significantly stimulated the release of immunoreactive growth hormone in vivo.
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© The Pharmaceutical Society of Japan
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