THE PREPARATION OF 14-HYDROXYLATED YOHIMBINE AND RESERPINE DERIVATIVES

Abstract

Hydroxylation at C-14 of yohimbine (6), pseudoyohimbine (7) and isoreserpine (8) was made through oxidation of the enamines (10, 15) with benzoyl or p-nitrobenzoyl peroxide followed by reduction with NaBH₄ and removal of benzoyl or p-nitrobenzoyl group to give the 14-hydroxylated compounds (13, 14, 22).