A Simple Linear Model for the Simulation of Plasma Concentration-Time Curves Based on the Two-Compartment Open Model

Abstract

A new in vitro model has been elaborated for the simulation of plasma concentration curves based on the two-compartment open model. The new method consists of a procedure in which vessels containing water or an aqueous solution of a drug are simply connected in a line and the contents are made to flow at a constant rate from one side to the other. The model is expected to be useful for the study of, for example, the in vitro antibacterial activity of antibiotics whose concentrations change according to the two-compartment open model.