Hydrolysis of Succinylcholine Chloride in pH Range 3.0 to 4.5

抄録

The influences of temperature, pH, buffer, ionic strength and initial drug concentration on the stability of succinylcholine chloride in aqueous solution were investigated. The following results were obtained : (i) in unbuffered solutions-the reaction was apparent zero order ; the pH fell during the course of reaction ; the rate of hydrolysis was slowest in solutions initially adjusted to pH 3.75-4.50, (ii) the rate of hydrolysis was significantly catalyzed by buffer, (iii) the rate of hydrolysis increased modestly with an increase in ionic strength, and (iv) the rate of hydrolysis increased with initial concentration of drug in solution.