Stereoselective Reduction of α-Methyl-β-hydroxy Ketones with Zinc Borohydride
キーワード:
lithium borohydride
1984 年 32 巻 4 号 p. 1411-1415
詳細
1984 年 32 巻 4 号 p. 1411-1415
Zinc borohydride reduction of α-methyl-β-hydroxy ketones 3 produced the erythro-2-methyl-1, 3-glycol derivatives 4 with high stereoselectivity. The selectivity was particularly high when an olefinic group was conjugated to the carbonyl group. Reduction of the same system with NaBH4 and LiBH4 showed poor selectivity.
