Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Synthetic Studies on Flavone Derivatives. XV. Isomerization of Chalcones into Flavanones in Methyl Cellosolve-Phosphoric Acid
飯沼 宗和松浦 信田中 稔幸
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1984 年 32 巻 4 号 p. 1472-1476

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Isomerization of a chalcone having several benzyloxyl groups into a flavanone by the use of phosphoric acid in methyl cellosolve was investigated, and higher yields of flavanones were obtained with much shorter reaction times than in the conventional procedure. The reaction was applied to the synthesis of three flavanones, agestricins B, C and D, isolated from Ageratum strictum. A chalcone, agestricin A, was also prepared to confirm its structure.
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© The Pharmaceutical Society of Japan
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