Fungal Metabolites. I. Isolation and Biological Activities of Hypelcins A and B (Growth Inhibitors against Lentinus edodes) from Hypocrea peltata

Abstract

Two new peptide antibiotics, hypelcins A and B, were isolated from Hypocrea peltata, which is antagonistic to Lentinus edodes. Hypelcins A and B are linear peptides which include nine or ten residues of the abnormal amino acid α-aminoisobutyric acid (Aib) and an amino alcohol, L-leucinol. Hypelcin A was confirmed to be an amide of hypelcin B by chemical conversion. Hypelcin A showed antifungal and antibacterial activities, and contractile action on guinea pig ileum.