Synthesis of Diclofenac

YASUMITSU TAMURA; JUNICHI UENISHI; HONGDAE CHOI; JUNICHI HARUTA; HIROYUKI ISHIBASHI

doi:10.1248/cpb.32.1995

YASUMITSU TAMURA, JUNICHI UENISHI, HONGDAE CHOI, JUNICHI HARUTA, HIROYUKI ISHIBASHI

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Keywords: oxindole (indolin-2-one)

JOURNAL FREE ACCESS

1984 Volume 32 Issue 5 Pages 1995-1997

DOI https://doi.org/10.1248/cpb.32.1995

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Abstract

Diclofenac, a potent antiinflammatory agent, was prepared by acid-catalyzed cyclization of N-(2, 6-dichlorophenyl)-α-(methylsulfinyl) acetanilide or of α-chloro-N-(2, 6-dichlorophenyl)-α-(methylthio) acetanilide followed by desulfurization and hydrolysis of the resultant 1-(2, 6-dichlorophenyl)-3-(methylthio) oxindole.

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