Studies on Positive Inotropic Agents. I. Synthesis of 3, 4-Dihydro-6-[4-(3, 4-dimethoxybenzoyl)-1-piperazinyl]-2 (1H)-quinolinone and Related Compounds

MICHIAKI TOMINAGA; EIYU YO; HIDENORI OGAWA; SHUJI YAMASHITA; YOUICHI YABUUCHI; KAZUYUKI NAKAGAWA

doi:10.1248/cpb.32.2100

MICHIAKI TOMINAGA, EIYU YO, HIDENORI OGAWA, SHUJI YAMASHITA, YOUICHI YABUUCHI, KAZUYUKI NAKAGAWA

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Keywords: biological activity

JOURNAL FREE ACCESS

1984 Volume 32 Issue 6 Pages 2100-2110

DOI https://doi.org/10.1248/cpb.32.2100

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Abstract

Many (1-piperazinyl)-2 (1H)-quinolinone derivatives were synthesized and examined for positive inotropic activities on the canine heart. Among them, 3, 4-dihydro-6-[4-(3, 4-dimethoxybenzoyl)-1-piperazinyl]-2 (1H)-quinolinone (XVIIb-1) was found to have a very potent activity.

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