抄録
1-Substituted 2 (1H)-pyrimidinones (I) underwent ring transformation with malononitrile and ethyl acetoacetate in the presence of sodium ethoxide to give 2-amino-3-pyridinecarbonitriles (II-VII) and N-(substituted) amino-3-pyridinecarboxylic acids (XIV and XV), respectively. Further, I reacted with ethyl cyanoacetate, dialkyl malonate, or ethyl benzoylacetate to give pyridine derivatives (VIII-XIII) bearing various functional groups at the C-3 position. The reaction of 1-substituted 2 (1H)-pyrimidinethiones and 4, 6-dimethyl-1-phenyl-2-phenylimino-1, 2-dihydropyrimidine with active methylene compounds is also discussed.
