A New Method for the Preparation of 2-(Alkylamino) benzoxazoles and 2-(Alkylimino) benzoxazolines

抄録

New syntheses of 2-(alkylamino) benzoxazoles (III) and 3-alkyl-2-(alkylimino) benzoxazolines (IV) were developed. Various compounds III were obtained by the reactions of 2-(methylthio) benzoxazole with amines. In the alkylation of 2-(monoalkylamino) benzoxazoles, the use of a base as a catalyst was found to be important for the selective preparation of 2-(N, N-dialkylamino) benzoxazoles ; in the absence of base, IV was obtained, On the other hand, alkylation of N, N'-dialkyl-N-(2-hydroxyphenyl) thioureas resulted in the development of another method for the preparation of IV.