Studies on Chemical Carcinogens and Mutagens. XXVI. Chemical Properties and Mutagenicity of Alkyl Alkanesulfonates on Salmonella typhimurium TA100

Abstract

The mutagenic and cytotoxic effects of 18 kinds of methyl, ethyl, and isopropyl esters of straight-chain alkanesulfonic acids including isethionic acid were investigated on Salmonella typhimurium TA100. In order to correlate these biological activities with the chemical and/or physicochemical properties, the hydrolytic rates (as a measure of alkylating ability) and the capacity factors (as a measure of hydrophobicity) were determined. Some structural correlations were apparent, although quantitative structure-activity relationships were not obtained.