SYNTHESIS OF DIASTEREOMERIC 24, 25-DIHYDROXYVITAMIN D2 AND SEPARATION OF ITS (24R)-AND (24S)-ISOMERS

Kotomi Katsumi; Toshio Okano; Tadashi Kobayashi; Okiko Miyata; Takeaki Naito; Ichiya Ninomiya

doi:10.1248/cpb.32.3744

SYNTHESIS OF DIASTEREOMERIC 24, 25-DIHYDROXYVITAMIN D₂ AND SEPARATION OF ITS (24R)-AND (24S)-ISOMERS

Kotomi Katsumi, Toshio Okano, Tadashi Kobayashi, Okiko Miyata, Takeaki Naito, Ichiya Ninomiya

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Keywords: vitamin D

JOURNAL FREE ACCESS

1984 Volume 32 Issue 9 Pages 3744-3746

DOI https://doi.org/10.1248/cpb.32.3744

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Abstract

Diastereomeric 24, 25-dihydroxyvitamin D₂ (I) was synthesized from ergosterol (II) through an efficient route and successfully separated into the (24R)-and (24S)-isomers by high-performance liquid chromatography (HPLC). The absolute configurations of the isomers were determined by co-chromatography with the authentic respective specimens.

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