INTERMEDIACY OF 10-HYDROXYGERANIOL, 10-HYDROXYNEROL AND IRIDODIAL IN THE BIOSYNTHESIS OF AJMALINE AND VOMILENINE IN RAUWOLFIA SERPENTINA SUSPENSION CULTURES

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Administration of ²H-and ¹³C-labeled compounds to Rauwolfia serpentina suspension cultures indicated that ajmaline (4) and vomilenine (5) produced by these cultures are biosynthesized via 10-hydroxygeraniol (6)/10-hydroxynerol (7) and iridodial (3) in the same way as secologanin (1), vindoline, etc. in Catharanthus roseus and Lonicera morrowii. Therefore, this cyclization mechanism seems likely to be common in plants containing secoiridoids and indole alkaloids.