Carbapenem and Penem Antibiotics. IV. Synthesis and Antibacterial Activity of (5R^*, 6S^*)-6-[(R^*)-1-Hydroxyethyl]-2-functionalized-methyl Carbapenem and Penem Derivatives

Abstract

Racemic 2-acetoxymethyl and 2-(heteroaromatic) thiomethyl carbapenem and penem antibiotics having a 1-(R^*)-hydroxyethyl side-chain at C-6 (6, 7, 8, and 45, 59, 47, 49, 51) were synthesized, and their antibacterial activities were determined.