Pyridonecarboxylic Acids as Antibacterial Agents. V. Synthesis of 1-Vinyl-1, 4-dihydro-4-oxo-1, 8- and 1, 6-naphthyridine-3-carboxylic Acids

Abstract

A series of 7-substituted 1, 4-dihydro-4-oxo-1-vinyl-1, 8- and 1, 6-naphthyridine-3-carboxylic acids (5a-e and 13a-c) was prepared. During the preparation of 5a, unexpected compounds (4, 7 and 8) were also obtained. Structural elucidation of these compounds was achieved on the basis of chemical and spectral (ultraviolet, mass and proton nuclear magnetic resonance) data. The structure-antibacterial activity relationships are discussed.