Reaction of 21-Bromo-17α-methoxy-20-ketopregnenes with Sodium Methoxide or Potassium Acetate

Abstract

The reaction of 21-bromo-3β-hydroxy-17α-methoxypregn-5-en-20-one (5) with NaOCH₃ in MeOH under reflux gave the 21-aldehyde 9 in modest yield along with the 21-hydroxy derivative 6. The 21-acetates 8 and 13 were obtained in good yields by prolonged reaction of the 21-bromides 5 and 11 with CH₃COO^-.