Abstract
In this study, the effect of cross-linking time on the adsorption characteristics of microcapsules containing activated charcoal (ACMC) was investigated. The microcapsules were prepared by the gelatin-acacia coacervation procedure. Activated charcoal powder was used as an adsorbent, and creatinine as a model adsorbate. The following results were obtained. The adsorption rate on ACMC could be controlled by changing the cross-linking time of the coacervate. A stable semipermeable membrane was formed by gelatin-acacia coacervation at cross-linking times greater than 60 min. Accordingly, the oral administration of ACMC should be available as a supporting technique in the treatment of patients with renal failure.
