Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Condensed Heteroaromatic Ring Systems. IV. Synthesis of Naphthyridine Derivatives by Cyclization of Aminopyridineacrylic Esters
TAKAO SAKAMOTO, YOSHINORI KONDO, HIROSHI YAMANAKA
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Keywords: pyridineacrylic ester
JOURNAL FREE ACCESS

1985 Volume 33 Issue 11 Pages 4764-4768

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Abstract
The reaction of aminohalopyridines with ethyl acrylate in the presence of palladium (II) acetate and triarylphosphine gave ethyl aminopyridineacrylates. The cyclization of the resulting acrylates under basic conditions gave naphthyridinones having a carbostyril-type moiety.
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© The Pharmaceutical Society of Japan
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