Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Platelet Aggregation Potentiators from Cho-Rei
WEI LUISAO ADACHIKENSAKU KANOAKIKO YASUTAKAZUO TORIIZUKAMASAHARU UENOISAMU HORIKOSHI
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Keywords: thrombosis
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1985 Volume 33 Issue 11 Pages 5083-5087

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Abstract

Four components were isolated from Cho-Rei (Polyporus umbellatus), one of the traditional Chinese medicines, and three of them potentiated the rabbit platelet aggregation response induced by collagen and/or adenosine-5'-diphosphate in vitro. The four components were identified as ergosta-7, 22-dien-3-one, ergosta-7, 22-dien-3-ol, 5α, 8α-epidioxy ergosta-6, 22-dien-3-ol and the already known component, ergosterol. When the C3-hydroxy group of the active components was replaced by a ketone group, the enhancing activity disappeared, and an inhibitory tendency was observed. This suggests a relationship between bioactivity and the C3-hydroxy group (or polarity) of these components.

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© The Pharmaceutical Society of Japan
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