Synthesis and Aldose Reductase Inhibitory Activity of N-Acylthiazolidinecarboxylic Acids

EISHIN KATO; KOJI YAMAMOTO; TOSHIO BABA; TOSHIO WATANABE; YOICHI KAWASHIMA; MASATO HORIUCHI; MASAYUKI OYA; TADASHI ISO; JUNICHI IWAO

doi:10.1248/cpb.33.5341

EISHIN KATO, KOJI YAMAMOTO, TOSHIO BABA, TOSHIO WATANABE, YOICHI KAWASHIMA, MASATO HORIUCHI, MASAYUKI OYA, TADASHI ISO, JUNICHI IWAO

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Keywords: (2R, 2'R, 4R, 4'R)-3, 3'-azelaoylbis [2-(3-nitrophenyl)-4-thiazolidinecarboxylic acid]

JOURNAL FREE ACCESS

1985 Volume 33 Issue 12 Pages 5341-5350

DOI https://doi.org/10.1248/cpb.33.5341

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Abstract

Various mono-and dithiazolidinecarboxylic acids were synthesized by acylation of (4R)-4-thiazolidinecarboxylic acids and tested for aldose reductase inhibitory activity in vitro. (2R, 4R)-3-(8-Carboxyoctanoyl)-2-(3-nitrophenyl)-4-thiazolidinecarboxylic acid (13) and (2R, 2'R, 4R, 4'R)-3, 3'-azelaoylbis [2-(3-nitrophenyl)-4-thiazolidinecarboxylic acid] (24) showed the most potent activity among them.

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