Abstract
Deacetyl-thymosin α11 was synthesized by successive azide condensations of seven peptide fragments, Boc-(1-3)-NHNH2, Boc-(4-7)-NHNH2, Boc-(8-11)-NHNH2, Boc-(12-16)-NHNH2, Boc-(17-22)-NHNH2, Boc-(23-26)-NHNH2 and Boc-(27-29)-NHNH2, with H-(30-35)-OBzl, followed by deprotection with hydrogen fluoride in the presence of anisole and thioanisole. An increase of E-rosette-forming cells was obtained after incubation of peripheral blood from a rheumatoid arthritis patient with the synthetic deacetyl-thymosin α11. This synthetic deacetyl-thymosin α11 was approximately equal in potency to our synthetic deacetyl-thymosin α1 in cases of rheumatoid arthritis.
