Synthesis and Immunological Effect of Deacetyl-thymosin α₁₁ on Low E-Rosette-Forming Cells of a Rheumatoid Arthritis Patient

抄録

Deacetyl-thymosin α₁₁ was synthesized by successive azide condensations of seven peptide fragments, Boc-(1-3)-NHNH₂, Boc-(4-7)-NHNH₂, Boc-(8-11)-NHNH₂, Boc-(12-16)-NHNH₂, Boc-(17-22)-NHNH₂, Boc-(23-26)-NHNH₂ and Boc-(27-29)-NHNH₂, with H-(30-35)-OBzl, followed by deprotection with hydrogen fluoride in the presence of anisole and thioanisole. An increase of E-rosette-forming cells was obtained after incubation of peripheral blood from a rheumatoid arthritis patient with the synthetic deacetyl-thymosin α₁₁. This synthetic deacetyl-thymosin α₁₁ was approximately equal in potency to our synthetic deacetyl-thymosin α₁ in cases of rheumatoid arthritis.