Synthesis of Alkyl-β-D-thioglucopyranosides, a Series of New Nonionic Detergents

抄録

As a part of our search for new types of detergent useful for biological applications, a series of alkyl-β-D-thioglucopyranosides was synthesized in several steps from glucose. The overall yield was about 80%. Critical micelle concentrations of n-hexyl-, n-heptyl-, n-octyl-, and n-nonyl-β-D-thioglucopyranoside were determined. Because of their electroneutrality, high solubility in water and high critical micelle concentration, n-heptyl-and n-octyl-β-D-thioglucopyranoside seem to be potentially useful detergents for applications in biological systems.