Synthetic Studies on an Antitumor Antibiotic, Bleomycin. XII. Preparation of an L-2, 3-Diaminopropionic Acid Derivative as a Synthetic Intermediate

MASAMI OTSUKA; ATSUSHI KITTAKA; TAKAMASA IIMORI; HARUO YAMASHITA; SUSUMU KOBAYASHI; MASAJI OHNO

doi:10.1248/cpb.33.509

Chemical and Pharmaceutical Bulletin

Online ISSN : 1347-5223
Print ISSN : 0009-2363

Synthetic Studies on an Antitumor Antibiotic, Bleomycin. XII. Preparation of an L-2, 3-Diaminopropionic Acid Derivative as a Synthetic Intermediate

MASAMI OTSUKA, ATSUSHI KITTAKA, TAKAMASA IIMORI, HARUO YAMASHITA, SUSUMU KOBAYASHI, MASAJI OHNO

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Keywords: (S)-3-amino-2-tert-butoxycarbonylaminopropionamide

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Volume 33 (1985) Issue 2 Pages 509-514

DOI https://doi.org/10.1248/cpb.33.509

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Abstract

Three methods have been developed for the preparation of (S)-3-amino-2-tert-butoxycar-bonylaminopropionamide suitably protected for use in the total synthesis of bleomycin.

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