Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Site-Selectivity in the Cyanation of 3-Substituted Pyridine 1-Oxides with Trimethylsilanecarbonitrile
TAKAO SAKAMOTOSOHICHI KANEDASUMIKO NISHIMURAHIROSHI YAMANAKA
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Keywords: cyanation
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1985 Volume 33 Issue 2 Pages 565-571

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Abstract
The cyanation of 3-halo-, 3-methoxy-, and 3-dimethylaminopyridine 1-oxide with trimethylsilanecarbonitrile gave predominantly the corresponding 3-substituted 2-pyridinecarbonitriles. The deoxygenation of nitropyridine 1-oxides to nitropyridines with the same reagent is also described.
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© The Pharmaceutical Society of Japan
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