Author's Organization：Department of Medicinal Chemistry Hiroshima University School of Medicine Department of Medicinal Chemistry Hiroshima University School of Medicine Department of Medicinal Chemistry Hiroshima University School of Medicine Urology Hiroshima University School of Medicine Department of Chemistry, College of General Education, Hirosaki University
A newly synthesized 18-membered hexaamine carrying an acetate moiety on each nitrogen, L2, has been demonstrated to be a more efficient dissolving agent that ethylenediaminetetraacetic acid for human urinary calculi whose major components are calcium phosphate and magnesium phosphate. L2 is a good chelating agent for Ca2+ and Mg2+, and this chelating action is presumably responsible for the dissolution of inorganic calculi.
